Journal of Human Genetics and Genomics

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Considering Exososomal MicroRNAs as Biomarkers in Multiple Sclerosis

Leila Zare 1 and Mahsa Motavaf 2 , *
Authors Information
1 Department of Physiology, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran
2 Department of Molecular Genetics, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran
Article information
  • Journal of Human Genetics and Genomics: July 2018, 2 (1); e81030
  • Published Online: July 29, 2017
  • Article Type: Editorial
  • Received: May 29, 2017
  • Accepted: June 23, 2017
  • DOI: 10.5812/jhgg.81030

How to Cite: Zare L, Motavaf M. Considering Exososomal MicroRNAs as Biomarkers in Multiple Sclerosis, J Human Gen Genom. 2018 ; 2(1):e81030. doi: 10.5812/jhgg.81030.

Abstract
Copyright © 2017, Journal of Human Genetics and Genomics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Conclusions
References
  • 1. Katz Sand I. Classification, diagnosis, and differential diagnosis of multiple sclerosis. Curr Opin Neurol. 2015;28(3):193-205. doi: 10.1097/WCO.0000000000000206. [PubMed: 25887774].
  • 2. Lublin FD, Reingold SC, Cohen JA, Cutter GR, Sorensen PS, Thompson AJ, et al. Defining the clinical course of multiple sclerosis: the 2013 revisions. Neurology. 2014;83(3):278-86. doi: 10.1212/WNL.0000000000000560. [PubMed: 24871874]. [PubMed Central: PMC4117366].
  • 3. Housley WJ, Pitt D, Hafler DA. Biomarkers in multiple sclerosis. Clin Immunol. 2015;161(1):51-8. doi: 10.1016/j.clim.2015.06.015. [PubMed: 26143623].
  • 4. Axisa PP, Hafler DA. Multiple sclerosis: genetics, biomarkers, treatments. Curr Opin Neurol. 2016;29(3):345-53. doi: 10.1097/WCO.0000000000000319. [PubMed: 27058221].
  • 5. Tkach M, Thery C. Communication by Extracellular Vesicles: Where We Are and Where We Need to Go. Cell. 2016;164(6):1226-32. doi: 10.1016/j.cell.2016.01.043. [PubMed: 26967288].
  • 6. Robbins PD, Dorronsoro A, Booker CN. Regulation of chronic inflammatory and immune processes by extracellular vesicles. J Clin Invest. 2016;126(4):1173-80. doi: 10.1172/JCI81131. [PubMed: 27035808]. [PubMed Central: PMC4811148].
  • 7. Karasu E, Eisenhardt SU, Harant J, Huber-Lang M. Extracellular Vesicles: Packages Sent With Complement. Front Immunol. 2018;9:721. doi: 10.3389/fimmu.2018.00721. [PubMed: 29696020]. [PubMed Central: PMC5904200].
  • 8. Janas AM, Sapon K, Janas T, Stowell MH, Janas T. Exosomes and other extracellular vesicles in neural cells and neurodegenerative diseases. Biochim Biophys Acta. 2016;1858(6):1139-51. doi: 10.1016/j.bbamem.2016.02.011. [PubMed: 26874206].
  • 9. Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol. 2011;29(4):341-5. doi: 10.1038/nbt.1807. [PubMed: 21423189].
  • 10. Pusic AD, Pusic KM, Kraig RP. What are exosomes and how can they be used in multiple sclerosis therapy? Expert Rev Neurother. 2014;14(4):353-5. doi: 10.1586/14737175.2014.890893. [PubMed: 24552578]. [PubMed Central: PMC4090348].
  • 11. Shukla GC, Singh J, Barik S. MicroRNAs: Processing, Maturation, Target Recognition and Regulatory Functions. Mol Cell Pharmacol. 2011;3(3):83-92. [PubMed: 22468167]. [PubMed Central: PMC3315687].
  • 12. Junker A, Krumbholz M, Eisele S, Mohan H, Augstein F, Bittner R, et al. MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47. Brain. 2009;132(Pt 12):3342-52. doi: 10.1093/brain/awp300. [PubMed: 19952055].
  • 13. Keller A, Leidinger P, Lange J, Borries A, Schroers H, Scheffler M, et al. Multiple sclerosis: microRNA expression profiles accurately differentiate patients with relapsing-remitting disease from healthy controls. PLoS One. 2009;4(10). e7440. doi: 10.1371/journal.pone.0007440. [PubMed: 19823682]. [PubMed Central: PMC2757919].
  • 14. De Santis G, Ferracin M, Biondani A, Caniatti L, Rosaria Tola M, Castellazzi M, et al. Altered miRNA expression in T regulatory cells in course of multiple sclerosis. J Neuroimmunol. 2010;226(1-2):165-71. doi: 10.1016/j.jneuroim.2010.06.009. [PubMed: 20637509].
  • 15. Backes C, Meese E, Keller A. Specific miRNA Disease Biomarkers in Blood, Serum and Plasma: Challenges and Prospects. Mol Diagn Ther. 2016;20(6):509-18. doi: 10.1007/s40291-016-0221-4. [PubMed: 27378479].
  • 16. Ebrahimkhani S, Vafaee F, Young PE, Hur SSJ, Hawke S, Devenney E, et al. Exosomal microRNA signatures in multiple sclerosis reflect disease status. Sci Rep. 2017;7(1):14293. doi: 10.1038/s41598-017-14301-3. [PubMed: 29084979]. [PubMed Central: PMC5662562].
  • 17. Selmaj I, Cichalewska M, Namiecinska M, Galazka G, Horzelski W, Selmaj KW, et al. Global exosome transcriptome profiling reveals biomarkers for multiple sclerosis. Ann Neurol. 2017;81(5):703-17. doi: 10.1002/ana.24931. [PubMed: 28411393].

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