Journal of Human Genetics and Genomics

Published by: Kowsar

Investigating the Association of rs1617640 Polymorphism in Patients with Diabetes Type II and Its Complications

Mehdi Roshanian 1 , Mohammad Amin Javidi 2 , Negin Jafarian 1 and Mohammad Hasan Sheikhha 3 , *
Authors Information
1 Genetics Biology, Ashkezar Branch, Islamic Azad University, Ashkezar, Iran
2 Department of Molecular and Cellular Science, Faculty of Advanced Sciences and Technology, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran
3 Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Article information
  • Journal of Human Genetics and Genomics: April 2017, 1 (1); e66884
  • Published Online: April 26, 2017
  • Article Type: Research Article
  • Received: February 25, 2017
  • Revised: March 14, 2017
  • Accepted: April 4, 2017
  • DOI: 10.5812/jhgg.66884

How to Cite: Roshanian M, Javidi M A, Jafarian N, Sheikhha M H. Investigating the Association of rs1617640 Polymorphism in Patients with Diabetes Type II and Its Complications, J Human Gen Genom. 2017 ; 1(1):e66884. doi: 10.5812/jhgg.66884.

Copyright © 2017, Journal of Human Genetics and Genomics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion and Conclusion
  • 1. Tong Z, Yang Z, Patel S, Chen H, Gibbs D, Yang X, et al. Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications. Proc Natl Acad Sci U S A. 2008;105(19):6998-7003. doi: 10.1073/pnas.0800454105. [PubMed: 18458324].
  • 2. Javidi MA, Zolghadr F, Babashah S, Sadeghizadeh M. Introducing Dendrosomal Nanocurcumin as a Compound Capable of in vitro Eliminating Undifferentiated Stem Cells in Cell Therapy Practices. Exp Clin Endocrinol Diabetes. 2015;123(10):632-6. doi: 10.1055/s-0035-1555775. [PubMed: 26179929].
  • 3. Flannick J, Florez JC. Type 2 diabetes: genetic data sharing to advance complex disease research. Nat Rev Genet. 2016;17(9):535-49. doi: 10.1038/nrg.2016.56. [PubMed: 27402621].
  • 4. Lacombe C, Mayeux P. The molecular biology of erythropoietin. Nephrol Dial Transplant. 1999;14 Suppl 2:22-8. [PubMed: 10334664].
  • 5. Moritz KM, Lim GB, Wintour EM. Developmental regulation of erythropoietin and erythropoiesis. Am J Physiol. 1997;273(6 Pt 2):R1829-44. doi: 10.1152/ajpregu.1997.273.6.R1829. [PubMed: 9435635].
  • 6. Lakerveld J, Bot SD, Chinapaw MJ, van Tulder MW, van Oppen P, Dekker JM, et al. Primary prevention of diabetes mellitus type 2 and cardiovascular diseases using a cognitive behavior program aimed at lifestyle changes in people at risk: Design of a randomized controlled trial. BMC Endocr Disord. 2008;8:6. doi: 10.1186/1472-6823-8-6. [PubMed: 18573221].
  • 7. Pi-Sunyer FX. How effective are lifestyle changes in the prevention of type 2 diabetes mellitus?. Nutr Rev. 2007;65(3):101-10. doi: 10.1111/j.1753-4887.2007.tb00287.x. [PubMed: 17425061].
  • 8. Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001;344(18):1343-50. doi: 10.1056/NEJM200105033441801. [PubMed: 11333990].
  • 9. Szkandera J, Absenger G, Stotz M, Weissmueller M, Winder T, Langsenlehner T, et al. The functional polymorphism of erythropoietin gene rs1617640 G>T is not associated with susceptibility and clinical outcome of early-stage breast cancer. Anticancer Res. 2012;32(8):3473-8. [PubMed: 22843933].
  • 10. Song Q, Zhang Y, Wu Y, Zhou F, Qu Y. Association of erythropoietin gene polymorphisms with retinopathy in a Chinese cohort with type 2 diabetes mellitus. Clin Exp Ophthalmol. 2015;43(6):544-9. doi: 10.1111/ceo.12505. [PubMed: 25675872].
  • 11. Amanzada A, Goralczyk AD, Reinhardt L, Moriconi F, Cameron S, Mihm S. Erythropoietin rs1617640 G allele associates with an attenuated rise of serum erythropoietin and a marked decline of hemoglobin in hepatitis C patients undergoing antiviral therapy. BMC Infect Dis. 2014;14:503. doi: 10.1186/1471-2334-14-503. [PubMed: 25227310].
  • 12. Pantazopoulos C, Iacovidou N, Kouskouni E, Pliatsika P, Papalois A, Kaparos G, et al. Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation. Biomed Res Int. 2016;2016:3567275. doi: 10.1155/2016/3567275. [PubMed: 27847811].
  • 13. Miskowiak KW, Rush AJ, Gerds TA, Vinberg M, Kessing LV. Targeting Treatments to Improve Cognitive Function in Mood Disorder: Suggestions From Trials Using Erythropoietin. J Clin Psychiatry. 2016;77(12):e1639-46. doi: 10.4088/JCP.15m10480. [PubMed: 27835716].
  • 14. Carelli S, Giallongo T, Viaggi C, Gombalova Z, Latorre E, Mazza M, et al. Grafted Neural Precursors Integrate Into Mouse Striatum, Differentiate and Promote Recovery of Function Through Release of Erythropoietin in MPTP-Treated Mice. ASN Neuro. 2016;8(5). doi: 10.1177/1759091416676147. [PubMed: 27789613].
  • 15. Frey H, Moreth K, Hsieh LT, Zeng-Brouwers J, Rathkolb B, Fuchs H, et al. A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia. Glycoconj J. 2017;34(3):393-404. doi: 10.1007/s10719-016-9722-y. [PubMed: 27600268].
  • 16. Hoeber D, Sifringer M, van de Looij Y, Herz J, Sizonenko SV, Kempe K, et al. Erythropoietin Restores Long-Term Neurocognitive Function Involving Mechanisms of Neuronal Plasticity in a Model of Hyperoxia-Induced Preterm Brain Injury. Oxid Med Cell Longev. 2016;2016:9247493. doi: 10.1155/2016/9247493. [PubMed: 27493706].
  • 17. Bartnicki P, Rysz J, Franczyk B, Baj Z, Majewska E. Impact of Continuous Erythropoietin Receptor Activator on Selected Biomarkers of Cardiovascular Disease and Left Ventricle Structure and Function in Chronic Kidney Disease. Oxid Med Cell Longev. 2016;2016:9879615. doi: 10.1155/2016/9879615. [PubMed: 27034745].
  • 18. Miskowiak KW, Vinberg M, Glerup L, Paulson OB, Knudsen GM, Ehrenreich H, et al. Neural correlates of improved executive function following erythropoietin treatment in mood disorders. Psychol Med. 2016;46(8):1679-91. doi: 10.1017/S0033291716000209. [PubMed: 26996196].
  • 19. Xu Q, Zhang C, Zhang D, Jiang H, Peng S, Liu Y, et al. Analysis of the erythropoietin of a Tibetan Plateau schizothoracine fish (Gymnocypris dobula) reveals enhanced cytoprotection function in hypoxic environments. BMC Evol Biol. 2016;16:11. doi: 10.1186/s12862-015-0581-0. [PubMed: 26768152].
  • 20. Garimella PS, Katz R, Patel KV, Kritchevsky SB, Parikh CR, Ix JH, et al. Association of Serum Erythropoietin With Cardiovascular Events, Kidney Function Decline, and Mortality: The Health Aging and Body Composition Study. Circ Heart Fail. 2016;9(1). e002124. doi: 10.1161/CIRCHEARTFAILURE.115.002124. [PubMed: 26721912].
  • 21. Divoky V, Song J, Horvathova M, Kralova B, Votavova H, Prchal JT, et al. Delayed hemoglobin switching and perinatal neocytolysis in mice with gain-of-function erythropoietin receptor. J Mol Med (Berl). 2016;94(5):597-608. doi: 10.1007/s00109-015-1375-y. [PubMed: 26706855].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments